'Put simply, the conundrum is this: Only 1.2 percent of the genome encodes proteins, but 80% of it is transcribed into RNA. So either the genome is replete with useless transcription, or these Noncoding RNAs fulfill some unexpected function! What was dismissed as junk because it was not understood may well turn out to hold the secrets to (human) complexity and a guide to the programming of complex systems in general! (John Mattick, 2004)'
Noncoding RNAs: Dark matter of the genome
The impact of Noncoding RNAs like microRNAs and long noncoding RNAs on eukaryotic gene regulation just started to be understood. The Kornfeld lab at the University of Southern Denmark takes part in this 'Noncoding RNA revolution' by identifying novel ncRNAs signaling circuits in energy homeostasis in health and metabolic disease. We apply state-of-the genomic art techniques like next-generation sequencing, transgenic mouse models and anti-ncRNA approaches in model organisms of metabolic disease to better understand the intricate biology of disease-associated ncRNAs. Our ultimatate goal is to define novel sequence-specific anti-ncRNAs therapeutics for anti-obesity intervention.