Welcome to the Kornfeld Lab, Hande!
Hande comes from Izmir, Turkey and is interested in how long noncoding RNAs regulate insulin sensitivity during satiety and under fasting conditions. She uses RNAi in primary hepatocytes against metabolically regulated lncRNAs and performs immunoblot analyses to study nutrient-dependent pathways like mTOR / AKT signaling.
Welcome to the Kornfeld Lab, Ines!
Ines studied in beautiful Salzburg (AT) and has a background in epigenetics and other Non-Mendelian carriers of genomic information. In her thesis, Ines pursues her scientific interests and aims to shed novel light onto how long noncoding RNAs and epigenome crosstalk to ultimately ensue brown adipose tissue and glucose homeostasis during both, normal physiology and metabolic disease.
Title: 'Epigenomic control of brown adipose tissue'
Title: ‘Using Systems Approaches to decipher Noncoding Principles of Energy Homeostasis’
Title: 'LINCing noncoding transcription to control of hepatic nutrient partitioning'
Title: 'De.Coding Obesity - Control of metabolism by the noncoding genome'
Title ‘Using Systems Approaches to decipher Regulatory Principles of Energy Homeostasis’
Title: 'de.Coding obesity_Control of metabolism by the noncoding genome'
Data visualisation scientist Paul Klemm has received the prestigious Karl-Heinz-Höhne MedVis Award in 2016.
This award is given out by the German Society for Informatics and honours scientists working at the interface of biomedicine and computer sciences and thereby contributed to better diagnostics and therapies using 'big data'. The awarding committee awarded Paul's PhD work conducted at the of the Otto-von-Guericke-Universität in Madgeburg.
In his work, Paul analysed datasets from large population cohorts to identify hitherto unknown risk factors underlying a broad spectrum of maladies, ranging from liver diseases to chronic back pain. These potential risk factors included lifestyle, hobbies or preexisting medical disorders. Paul's novel method will aid physicians and medical personnel in making more accurate diagnoses and prescribing more personalized therapies.
(Photocopyright: Veronika Solteszova)
Welcome to the Kornfeld Lab, Rute!
Rute did her PhD at the IDIBELL in Barcelona working on epigenetics and cancer. She has broad experience in epigenomics and DNA methylomics. Rute will contribute expertise in these fields to the lab and is interested in studying how epigenomic marks control adipose tissue plasticity under different nutritional cues like fasting and obesity.
Welcome to the Kornfeld lab, Paul!
Paul Klemm is a visualisation scientist from the U Magdeburg with a background in interpreting and visualising quantitative data from epidemiological studies.
Paul brings a computational mindset to the lab in order to better understand global transcriptomic and epigenomic events arising during obesity-associated deterioration of hepatic and adipose tissue metabollism.
Welcome to the Kornfeld Lab, Paul!
Lifestyle in fathers affects the fate of their offsprings!
The recently demonstrated nongenetic crosstalk between generations in a variety of model organisms is reminiscent of the longterm refuted concept of Lamarckian inheritance. According to this, environment and lifestyle cause phenotypic changes in coming generations, despite the latter never exposed to these conditions themselves. Although poorly understood in terms of the underlying molecular principles, first evidence pinpoints towards noncoding RNAs in the germline as crucial mediators for this transgenerational crosstalk.
In this review, Elena summarizes our current understanding of how RNAs might be implicated in this exiting mode of inheritance.
Matteo and Elena identify a novel microRNA signaling pathway that sheds new light on the known association between neurodegenerative diseases and obesity!
In their work, they identified two small, noncoding RNAs termed microRNA193b and microRNA328 that control glucose metabolism in mice by silencing the expression of a gene called Bace1 whose overexpression is suggested by many researchers to underly development and progression of Alzheimer's disease (AD).
Matteo and Elena could show that also during obesity, Bace1 is elevated in a metabolically hyperactive organ termed brown adipose tissue (BAT). Small-molecule inhibition of Bace1 improved glucose metabolism in obese mice via activation of BAT function. Therefore, pharmacological treatment with Bace1 inhibitors might emerge as innovative approach not only against AD but also obesity and type 2 diabetes!
(PS: Matteo is on the left!)
We are happy that the European Research Council (ERC) will fund our research with a Starting Grant in the upcoming 5 years. This will allows us to answer how noncoding RNAs like long, noncoding RNAs (lncRNAs) control glucose metabolism and energy homeostasis in vivo.
Furthermore we would like to better understand how environmental cues in fathers like obesity or caloric restriction affect the metabolic trajectory of their offsprings. This potentially nongenetic or 'Larmackian' control of metabolism across generations has important ramifications in the face of the continuing obesity pandemic.
Jan-Wilhelm in conjunction with Leo Kurian (ZMMK, CECAD) and Roman-Ulrich Müller (CECAD) is happy to announce NonCode 2015- a CECAD Mini-Symposium on Regulatory RNAs taking place on 24th August at the CECAD Research Center.
With the advent of modern sequencing techniques, regulatory RNA biology is gaining significant focus in myriads of avenues ranging from control of development to ageing and ageing-associated diseases. We bring together a group of young, internationally acclaimed scientists specializing in diverse aspects of RNA biology ranging from novel mechanisms of alternative splicing to single cell RNA sequencing. This will be a great opportunity to familiarize with the latest developments in regulatory RNA biology.
In order to facilitate easy and convenient scientific exchange, this symposium is free and registration is not required.
For more information please check:
The Young Academy of Europe (YAE) has been founded in 2007 by the European Research Council (ERC) under the claim "Supporting the next generation of research leaders in Europe".
The YAE constitutes a constantly evoving, interdisciplinary group of top european researchers at the junior PI levels. Its mission revolves around four main pillars:
- Fostering interdisciplinary scientific exchange
- Reaching out to policy makers at the European level
- Networking and support of emerging scientists within Europe
- Communication of research to the public
Nils Hansmeier was selected into the Cologne Cluster of Excellence: Cellular Stress Reponses in Ageing-Associated Diseases (CECAD) graduate school. He recently joined the Kornfeld lab to study the role of long, noncoding RNAs (lncRNAs) involved in glucose homeostasis and development of type 2 diabetes. His exciting work aims to unravel which obesity-associated lncRNAs could represent novel targets for in vivo lncRNA inhibition (RNAi). Ultimately, this could lead to a new class of anti-obesity, antisense-RNA therapeutics.
Great success for Elena!
In a competitive selection process, Elena was selected for the multi-disciplinary academy of the Evangelisches Studienwerk Villingst. Outstaning graduate students get the chance to broaden their scientific horizon by exchange with PhD students from other disciplines as well as participation in cultural activities.
The academy funds Elena's work on the role of long, noncoding RNAs in control of glucose metabolism and type 2 diabetes.
More than 100 attendants listened to talks from experts like Stefanie Dimmeler and Gunter Meister on their recent findings towards the biology of non-coding RNAs (ncRNAs). Other speakers from within CECAD and abroad presented novel insights into recent computational efforts to better understand ncRNA function, highlighted the complex control of gene expression by ncRNAs and presented data obtained from ncRNA loss-of-function animal models.
Data from our group and others also showed that anti-ncRNA compounds are increasingly used to treat ageing-associated diseases like type 2 diabetes and cardiovascular disease in animal models and preclinical test - thus underscoring the therapeutic potential of 'anti-RNA medicine'.
This great success for the first CECAD non-coding RNA Symposium underlines the tremendous scientific interest in this novel field of biomedical research.
The discovery that the noncoding space of eukaryotic genomes gives rise to a wide spectrum of noncoding RNAs has revolutionized our understanding of genomic regulation. Roman-Ulrich Müller and Jan-Wilhelm Kornfeld are happy to announce the first CECAD symposium on noncoding RNAs. The event will take place on the 28th of April 2014 in the new CECAD research building. Experts like Profs. Gunter Meister, Stefanie Dimmeler and others in conjunction with CECAD researchers will present their research aimed at better understanding the system-wide regulation of health and disease by noncoding RNAs.
For further details see:
Description of the webinar:
Noncoding RNAs make up the majority of transcribed RNA and have a wide range of functions in cellular and developmental processes. Consequently, they are also implicated in the development and pathophysiology of many diseases and represent potential targets for therapeutic intervention. microRNAs are one class of noncoding RNA that has been intensely studied. Effective inhibition (or silencing) of microRNAs in vivo has enabled scientists to make groundbreaking discoveries about the contribution of these short regulating RNAs to some of the major human diseases, such as cancer, heart disease, and diabetes. Long noncoding RNAs are less well studied, but have recently emerged as another novel class of therapeutic targets in a variety of diseases. Both long and short noncoding RNAs represent new avenues of investigation for drug discovery with several advantages over traditional protein-based targets; however, they come with their own unique set of challenges.
During the webinar the expert panel:
- Introduced the concept of using noncoding RNAs as therapeutic targets in human disease
- Discussed the unique challenges of targeting functional RNA in vivo
- Described recent advances enabling effective in vivo inhibition of noncoding RNA
- Answered audience questions during the live webinar.