Lifestyle in fathers affects the fate of their offsprings!
The recently demonstrated nongenetic crosstalk between generations in a variety of model organisms is reminiscent of the longterm refuted concept of Lamarckian inheritance. According to this, environment and lifestyle cause phenotypic changes in coming generations, despite the latter never exposed to these conditions themselves. Although poorly understood in terms of the underlying molecular principles, first evidence pinpoints towards noncoding RNAs in the germline as crucial mediators for this transgenerational crosstalk.
In this review, Elena summarizes our current understanding of how RNAs might be implicated in this exiting mode of inheritance.