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“The reality of thousands of novel noncoding RNA 'genes' will open therapeutic avenues for fighting ageing-related diseases"
My research interest lies within the identification, molecular understanding and therapeutic targeting of signaling pathways dysregulated in two classical ageing-related diseases: Cancer and obesity-associated insulin resistance.
Next-Generation RNA Sequencing efforts have revealed the pervasive transcription of mammalian genomes which gives rise to thousands of noncoding RNA (ncRNA) genes, the number of which probably matches that of classical, protein-coding genes. Better understanding the regulatory principles excerted by these ncRNA, which are often expressed in a temporally and spatially specific manner, will hopefully lead to novel anti-ncRNA therapeutics against complex diseases.