Learn more about Joo Hyun's research

 

"The parental epigenome will tell us the way to prevent metabolic diseases."

My research interest is the understanding of a transgenerational inheritance of diet-induced traits through epigenetic mechanisms. During my Ph.D. study, I explored a mechanism by which the effects of obesity in male mice are transmitted to the next consecutive generations. I found several epigenetic alterations, particularly DNA methylation, in the germ cell of obese founder and proposed that the epigenetic marks contribute to the alteration of hepatic transcripts in the offspring.

Recent researches have shed new light on the transgenerational inheritance of obesity via noncoding RNAs, but the exact mechanisms underlying the altered biology of noncoding RNAs in germ cells are still unclear. I hope to make contributions to the field of research at the Kornfeld Lab by investigating noncoding RNAs-mediated epigenetic regulation during germ-line transmission. Our work will provide an insightful evidence for how acquired obesity affects the onset of metabolic disease in next generations.